Leishmanicidal Activity of Passifloricin A and Derivatives

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چکیده

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Leishmanicidal activity of passifloricin A and derivatives.

Several natural and hemisyntetic passifloricins were assayed against Leishmania panamensis amastigotes. High leishmanicidal activity as well as toxicity was observed. The structure of a new compound is also reported.

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OBJECTIVES Previously, some nitroheteroaryl-1,3,4-thiadiazole derivatives were identified to have potent activity against Leishmania sp. The present aim was to complete the in vitro analysis, thereby investigating the in vivo efficiency of the analogues 15a, 21a and 21b against infected BALB/c mice. METHODS Following parasite inoculation and intraperitoneal drug administration (5 and 20 mg/kg...

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antioxidant and antimicrobial activity of allium jesdianum extract

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Chemical composition and leishmanicidal activity of Pulicaria gnaphalodes essential oil

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ژورنال

عنوان ژورنال: Molecules

سال: 2004

ISSN: 1420-3049

DOI: 10.3390/90800666